FOSAPREPITANT 150 mg

Neurokinin-1 (NK-1) Receptor Antagonist – Antiemetic for Chemotherapy-Induced Nausea and Vomiting (CINV)

ATC Code: A04AD12 | Prescription Only

---

Product Description:

Fosaprepitant dimeglumine is a water-soluble prodrug of aprepitant, and a selective neurokinin-1 (NK-1) receptor antagonist. After intravenous administration, it is rapidly converted to aprepitant, which blocks substance P from binding to NK-1 receptors in the central nervous system. This mechanism provides effective protection against both the acute and delayed phases of chemotherapy-induced nausea and vomiting (CINV). Fosaprepitant is typically used as part of a triple antiemetic regimen with a 5-HT3 antagonist and dexamethasone.

Available Presentation:

• Strength: 150 mg per vial
• Formulation: Lyophilized powder for reconstitution
• Packaging: Single-dose vial in carton
• Route of Administration: Intravenous infusion
• Reconstitution: Reconstitute with 5 mL sterile water, dilute in 100 mL saline or dextrose
• Storage: 2°C to 8°C; protect from light; do not freeze

Uses:

• Prevention of acute and delayed CINV in patients receiving:
  • Highly emetogenic chemotherapy (HEC)
  • Moderately emetogenic chemotherapy (MEC)
• Single-dose IV alternative to 3-day oral aprepitant therapy
• Utilized in adult and pediatric oncology protocols (age ≥6 months)

Indications:

• Adults and children (≥6 months): Prevention of CINV associated with:
  • Initial and repeat cycles of highly or moderately emetogenic chemotherapy
• Acute and delayed CINV: Effective up to 120 hours post-chemotherapy
• Patients unable to tolerate oral agents or requiring simplified dosing regimens

Regulatory and Safety Profile:

• ATC Code: A04AD12
• WHO Essential Medicines List: Not listed
• Pharmacologic Class: NK-1 Receptor Antagonist (IV)
• Contraindications: Known hypersensitivity to fosaprepitant or aprepitant
• Common Side Effects: Fatigue, diarrhea, hiccups, neutropenia, infusion site reactions
• Drug Interactions: CYP3A4 substrate; monitor corticosteroids, warfarin, and oral contraceptives
• Pregnancy Category: B – Use only if clearly needed
• Monitoring: Liver function tests, review of concurrent medications, infusion-site monitoring

---

For quotations, biosimilar sourcing, or regulatory dossiers for Latin American distribution, contact our commercial team at info@panamfarma.com.