PALONOSETRON 0.25 mg / 5 mL

Antiemetic – 5-HT3 Receptor Antagonist

Product Description:

Palonosetron is a second-generation serotonin (5-HT3) receptor antagonist, specifically designed for the prevention of chemotherapy-induced nausea and vomiting (CINV). With a long half-life (~40 hours) and a high receptor binding affinity, it provides extended protection from both acute and delayed phases of CINV in patients receiving moderately or highly emetogenic chemotherapy.

Available Presentation:

• Strength: 0.25 mg / 5 mL
• Form: Solution for Intravenous Injection
• Packaging: Single-dose vial
• Route of Administration: Intravenous (IV) bolus or infusion
• Storage: Room temperature (15°C to 30°C); protect from light

Uses:

• Prevention of acute nausea and vomiting associated with moderately emetogenic chemotherapy (MEC)
• Prevention of delayed nausea and vomiting following highly emetogenic chemotherapy (HEC)
• Commonly used in combination with corticosteroids and NK-1 receptor antagonists

Indications:

• Adults: Prevention of nausea and vomiting with initial and repeat courses of:
  • Moderately emetogenic chemotherapy (MEC)
  • Highly emetogenic chemotherapy (HEC)
• Off-label: Occasionally used for postoperative nausea and vomiting (PONV)

Regulatory and Safety Profile:

• ATC Code: A04AA05
• Pharmacologic Class: Selective 5-HT3 Antagonist
• WHO Essential Medicines List: No
• Contraindications: Hypersensitivity to Palonosetron or its components
• Common Adverse Effects: Headache, constipation, dizziness, fatigue
• Pregnancy Category: B (use only if clearly needed)

For inquiries regarding wholesale pricing, hospital distribution, or regulatory documentation, please contact our team at info@panamfarma.com.